ORIGINAL ABSTRACT

Glyphosate-based herbicides (GBHs) are organophosphate pesticides, which interrupt the chemicals involved in the endocrine system and cause lifelong disorders in women's reproductive system. The current study was designed to systematically evaluate the association between GBH exposure and the female reproductive tract. According to PRISMA Guidelines, the systematic review was performed, searching online databases, including Google Scholar, Web of Science, PubMed, and Scopus, throughout April 2020. Studies with Rodent, lamb, and fish or exposed to GBH to affect the female reproductive system were selected. All studies were in the English language. Two investigators independently assessed the articles. The first author's name, publication date, animal model, age, sample size, gender, dose, duration, and route of exposure and outcomes were extracted from each publication. The present review summarizes 14 publications on uterus alterations and oocytes, histological changes ovary, and assessed mRNA expression, protein expression, serum levels progesterone, and estrogen and intracellular Reaction Oxygen Species (ROS) in rodents, fish, and lamb exposed to GHB exposure. Most of the studies reported histological changes in ovarian and uterus tissue, alterations in serum levels, and increased oxidative stress level following exposure to GBH. Additionally, due to alterations in the reproductive systems (e.g., histomorphological changes, reduction of the mature follicles, higher atretic follicles, and interstitial fibrosis), it seems the GBH-induced female these alterations are both dose- and time-dependent. The present findings support an association between GBH exposure and female reproductive system diseases. However, more studies are needed to identify the mechanisms disrupting the effects of GBH and their underlying mechanisms. Considering the current literature, it is recommended that further investigations be focused on the possible effects of various pesticides on the human reproductive system.