ORIGINAL ABSTRACT

This study analyzes global data on human exposure to pesticides, focusing on glyphosate, POPs, carbamates, and organophosphates, which are among the most widely used in agricultural and urban environments, providing an overview of global human contamination by these substances. Current research has increasingly focused on the unintended consequences of pesticide use, including food, water, and soil contamination, biodiversity loss (especially beneficial insects such as pollinators), and the growing evidence of adverse impacts on human health (neurological, reproductive, endocrine, and carcinogenic effects). Therefore, we compiled information from several existing studies that evaluated pesticide residues in human biological samples, specifically urine, blood, and breast milk, to assess the extent of exposure. The analysis takes a global perspective, highlighting the importance of monitoring exposure in countries that demonstrate exceptionally high pesticide use (in terms of absolute volume), such as Brazil, the United States, and China, which are among the largest global consumers. The data cover both contemporary pesticides, whose consumption is driven by intensive agriculture in these and other countries, and persistent legacy compounds (POPs) that continue to circulate in nature and accumulate in the human body decades after their ban in many countries. Globally, there is a wide disparity in global regulations, and many developing countries continue to use pesticides that have been banned or severely restricted in more developed nations. Finally, it provides a critical overview of global data on human pesticide contamination. The data reinforce the critical importance of establishing preventive initiatives and strengthening surveillance and monitoring systems to detect and control pesticide residues in human populations globally, ultimately aiming to mitigate the harms of chronic pesticide exposure to human health and well-being.